Tuning stable noble metal nanoparticles dispersions to moderate their interaction with model membranes

The properties of stable gold (Au) nanoparticle dispersions can be tuned to alter their activity towards biomembrane models. Au coating techniques together with rapid electrochemical screens a phospholipid layer on fabricated mercury (Hg) platinum (Pt) electrode have been used moderate the dispersions. Screening results for were intercalibrated large unilamellar vesicle (LUV) interactions using carboxyfluorescein (CF) leakage assay. All characterised size, by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Commercial high quality home synthesised are monolayer active whereas Ag not. If nanoparticles coated thin then particle/lipid interaction is suppressed. assays lipid align LUV same. decreasing size increasing dispersion concentration showed stronger monolayer/bilayer interaction. Treating cell culture medium incubation in phosphate buffered saline (PBS) solutions removes